Slitterheadhas many jarring and shocking moments that can surprise you as you make your way through the main story, making the actions of some of the Rarities seem downright sinister, which helps build the tension and atmosphere as you get closer to the finale.

Tracking down the Doctor and eliminating the Slitterhead Family is one such moment, but having to go through it again during Ghost Family RE (2nd Loop) makes it clear that Alex may not be approaching this in a sane or moral way, leading the charge is a vicious and evil manner.

Selecting Alex and Edo for the Ghost Family RE (2nd Loop) mission in Slitterhead.

Starting Ghost Family RE (2nd Loop)

Revisiting the slums of the Slitterhead Doctor and Family for theGhost Family RE (2nd Loop)mission willforce you to use Alex as your primary Rarity,leaving only theCompanion Rarity slot openfor your choosing. We, of course, went withEdo,as he isarguably the best Rarityin the game thanks to hishigh damage outputandBurning Edge Skill.

Julee, Anita, and Tri will also work wellfor this mission, but westrongly recommend Edo,as his Skills can make some encounters trivial. Nonetheless, whoever you choose will be taking a backseat toAlex,as hisBlood Well and Bloody Blast combo is still extraordinarily strongand can punch through many fights as well.

A look at the rewards obtained for clearing Ghost Family RE (2nd Loop) for the first time in Slitterhead.

Confront The Doctor

At thestart of the mission,you will bestanding directly in front of the Doctor’s Office,allowing you toenter as soon as you gain controlof Alex. Once inside the Office, navigate to theLockers in the back right cornerand interact with them toopen up the secret passageinto the basement.

Follow the pathway into the basementto find theDoctorworking at a desk.Approach him to trigger a brief cutscene,having him flee from the Office, having Alexchase him down.You canland several hits on him as he runs out of the Office,but you won’t be able to do anything significant to him just yet.

Chase The Doctor

Chase after the Doctor until he runs into a small roomdeep in the slums, forcing him to fight you. YourRarities won’t be hereat the start of the encounter, but it’snot too challenging.Keeppossessing the residentsin the room to get behind him,thenland several hits on him before jumping to someone elseand repeating the loop.

Dropping the Doctor’s health down halfwaywill haveanother Slitterhead enter the room,allowing theDoctor to escape.You mustdeal with this Slitterheadbefore moving any further. Luckily, yourRarity will show up,allowing you tomake quick work of them with Burning Edge(if you chose Edo as your Companion).

If yourCompanion isn’t Edo,you can useAlex’s Blood Well and Bloody Blast comboto also dispatch the Slitterhead quickly. Whoever yoursecond Rarityis, they should be able toclean up from there,especially if they have their Skills primed and ready to go!

Continue Chasing The Doctor

With the other Slitterhead taken care of, exit the small room and chase after the Doctorinto theabandoned lot,finding him in his human form. As you approach him,he will turn back into a Slitterhead and will flee the sceneonce more, forcing you touse Blood Jump to keep on his tail.

Stay after him until he reaches the courtyardin the center of the slums andapproach him to trigger another brief cutscene,having him transform into the Flying Squid Slitterhead. Prepare for battle!

Defeat Flying Squid Slitterhead

After chasing the Doctor into the courtyard, he will transform into theFlying Squid Slitterhead,letting out athunderous roarthe instant the encounter begins. This roar will place theWeakening Ward(Level 1) andCorrosion Ward(Level 1) on everyone in the area,lowering their Maximum Health slightlyandreducing their Blood Weapon’s durability.

As soon as yougain control of Alex,unleash hisBlood Well and Bloody Blast comboon the Slitterhead, thenkeep up the pressurebyswitching to nearby residents and landing attacks on his backsideto quicklystaggerhim. Once he’s staggered, you canland several uncontested hitson him for massive damage.

While this encounter is the average run-of-the-mill encounter in Slitterhead, theDoctor has one move you should be wary of,and that’s hisgrabthatcannot be guarded or parriedagainst. The moment you see theSlitterhead emit a bright red light, get far away from himto avoid the incoming attack.

Mixing inBurning Edge with your Blood Well and Bloody Blast combo will have the Doctor finished in no time,so long as you canheal up between each combo,as it will use up much of Alex’s health. Don’t forget toswitch to a random civilian,useWar Cry,and thenjump back to Alex to healwithout interruption!

Now that the Doctor is taken care of, it’s time todeal with the Slitterhead Family.Again. Which is just as depressing as it was the first time around.Run up the stairs in the courtyard, turn right, and follow the alleywayuntil you reach theapartment complex.Once inside,interact with the elevator to trigger a cutscene,causing theDaughter to fleeagain, just like she did during the standard mission.

Chase The Daughter

Beginchasing after the Daughter,tailing behind heracross the rooftopsof the slums until you areambushed by a couple of lesser Slitterheads.Make quick work of them with your Blood Weapon, then push onward. Theyshouldn’t be much of a threat,as they are only here to slow you down.

From here, you will have tofollow her aura to track her down,leading you to thetop of another rooftop,where you willfind her doubled over in despair.Approach her toget jumped by several more lesser Slitterheads,having her escape the area yet again.Deal with these Slitterheads the same way you did the others,then continue the chase.

Continue Chasing The Daughter

Continue following the Daughter’s aurato eventuallyfind her on another rooftop,devastated by despair again.Approach her to get ambushedbymore Slitterheads,allowing you toquickly deal with themby using Alex’sBlood Well and Bloody Blast combo,finishing them off withBurning Edge.

Next,follow after her aura againuntil youreach the top of a building that looks down over an empty lot,where theDaughter will be hunched overagain by the despair you brought upon her.Make your way down to the empty lotto beambushed by a lone Slitterhead.

Thislone Slitterhead won’t put up much of a fightuntil you get it down tohalf health,where it willtransforminto anOctopus Slitterhead.Making things slightly more challenging, but not by too much.

Defeat Octopus Slitterhead

Knocking thelone Slitterhead’s health down halfwaywill have it transform into anOctopus Slitterhead,but it won’t be a proper boss, so it’sa bit weaker than it typically would be.We strongly recommendgetting behind it by way of possessiontoland hits on its dangling body,as that willstaggerit faster.

Of course,Alex’s Blood Well and Bloody Blast combo will also work flawlessly here,allowing you to end this fight in seconds.Once it’s stunned, toss everything you have at it,thenswitch to your Companion Rarity to finish it off,allowing the other one to recover afterward.

Despite not being much of a challenge, thisOctopus Slitterhead does have one action to be wary of,and that’s itsPouncing Attack,which istelegraphed by a flashing red light,signifying that itcannot be guarded or parried.When you see this,simply run away from it to avoid damage.Then reapply your offense until it’s dead!

Defeat Weedy Scorpionfish Slitterhead

Running into thelarge abandoned lotafter defeating the Octopus Slitterhead will trigger a cutscene, having the Daughter turn into theWeedy Scorpionfish Slitterheadagain, forcing you to take it down. As soon as the encounter begins, useAlex’s Blood Well and Bloody Blast comboto deal considerable damage off the rip.

Occasionally, theSlitterhead will perform a Lunging Strikethat is telegraphed with abright red light,indicating the movecannot be blocked or parried,sorun away from her the moment you see this.Other than that, you should be more than fine, asthis is the same exact encounter from the initial mission.

When it’s available,activate Burning Edge,anduse the Blood Well and Bloody Blast combo frequentlyto defeat this Slitterhead quickly. Fueling Alex’s monstrous impulses to destroy every last Slitterhead, no matter the cost.

Ghost Family RE (2nd Loop) Rewards

Annihilating the Slitterhead Family once more inGhost Family RE (2nd Loop)will net you a whopping30 Skill Tokensthat can be spent how you see fit. Thoughthey are shared,so once you confirm them on something, they are gone forever and cannot be used on another Rarity.

More ‘Talk’ dialogues will become availableupon clearing this mission, so exhaust all of them before moving on to anything else in the game, as it willunlock additional missions!